Success stories from projects

2018

‘We found a way to share the unsharable’ – an interview with the eTOX project coordinators

31/07/2018
​​​​​​​The eTOX project partners developed innovative strategies and novel software tools to better predict the safety and side effects of new candidate medicines for patients. In an interview with the IMI Programme Office, project coordinator Francois Pognan of Novartis, and academic coordinator Ferran Sanz of Institut Hospital del Mar d'Investigacions Mèdiques, explain how the tools developed by the project are already helping pharmaceutical companies make better-informed decisions in their pursuit of developing safer drugs for patients.
Francois Pognan

‘Radical collaboration’ is shaking up the pharmaceutical industry – Carlos Moedas

28/06/2018
‘Radical collaboration’ where multinational companies work together and share data instead of keeping it secret is helping to change the model of the pharmaceutical industry and solve problems more quickly, according to Carlos Moedas, the EU’s commissioner for research, science and innovation.
Illustrative image

Mobile technology solutions to monitoring medicines

21/06/2018
IMI's WEB-RADR project has developed a mobile app enabling patients and healthcare professionals to more easily report suspected adverse drug reactions. It has also analysed social media to assess drug safety. Both initiatives have shown potential for strengthening the monitoring of medicines.
Illustrative image

Developing liquid biopsy tests to diagnose cancer

14/06/2018
Liquid biopsies can help to diagnose cancer in its early stages, and assist clinicians in monitoring the impact of treatment at any point. IMI's CANCER-ID project has validated a series of tests for cancer cells to help develop more effective methods of diagnosis and more personalised treatments for lung and breast cancer - two of the most frequent malignancies in Europe.
Microscope

A faster way to spot the tell-tale signs of cancer-causing drugs

08/06/2018
IMI's MARCAR project has identified potential biomarkers that could indicate how likely a drug is to cause cancer at an earlier stage of testing than is currently possible, which could save drug companies time and money – and lead to safer drugs reaching patients faster.
Illustrative image

Complex diseases get the big data treatment

23/05/2018
​​​​​​​The big data explosion, which allows scientists to analyse factors such as people’s lifestyles, genes and medical records to develop personalised treatments for conditions, has so far mostly benefitted rare diseases with simple causes. But now, thanks to IMI's BigData @ Heart and ROADMAP projects, complex problems such as cardiovascular disease and dementia are getting the big data treatment.
ECG line

‘The benefits of collaboration come through loud and clear’ – an interview with the GETREAL project coordinator

22/05/2018
GETREAL developed new tools and resources for incorporating real-life data into drug development, which could increase confidence in new medicines and help to get them to patients more quickly. In an interview with the IMI Programme Office, project coordinator, Elaine Irving of GlaxoSmithKline explains the main project achievements, and why they wouldn’t have been possible without IMI.
Elaine Irving

Rise in vaccine hesitancy related to pursuit of purity – Prof. Heidi Larson

26/04/2018
​​​​​​​The rise of alternative health practices and a quest for purity can partly explain the falling confidence in vaccines which is driving outbreaks of preventable diseases such as measles, according to Heidi Larson, professor of anthropology, risk and decision medicine at the UK’s London School of Hygiene & Tropical Medicine, who is involved in two IMI projects: EBODAC and ADVANCE. In her interview with the Horizon Magazine, she explains how the two IMI projects are contributing to understanding drivers of vaccine confidence and developing interventions to build trust.
Heidi Larson

Tapping the full potential of Europe's health data

17/04/2018
IMI's EMIF project is helping researchers tap into Europe's treasure trove of electronic health data, saving them time and money in their quest to cure and develop better drugs for debilitating diseases. The effort has already led to promising findings linked to Alzheimer's and obesity.
Patient health records, illustrative

‘We made significant breakthroughs’ – an interview with the PREDECT project coordinators

16/04/2018
IMI’s PREDECT project developed new, much-improved laboratory models of cancer, which could improve the accuracy with which pharmaceutical companies predict the effectiveness of new drugs. In an interview the IMI Programme Office, project coordinator John Hickman of Servier, and academic coordinator Emmy Verschuren of the Institute for Molecular Medicine Finland at the University of Helsinki, explain the project’s most significant breakthroughs, and how these achievements will help in the future search for new drugs.
Emmy Verschuren

‘We made significant accomplishments in a very challenging field’ – an interview with MIP-DILI project coordinators

09/04/2018
IMI’s MIP-DILI project deepened the knowledge of the science behind drug-induced liver injury (DILI) and improved laboratory tests in use to predict DILI in the early stages of drug development. In an interview with the IMI Programme Office, Richard Weaver of Servier and academic coordinator, Kevin Park of the University of Liverpool, describe the project’s most important achievements, and explain how they are already benefitting industry, academia, and patients, while at the same time reducing the use of animals in research.
MIP-DILI logo

Patients are already benefiting from our project – an interview with the OncoTrack coordinators

05/04/2018
​​​​​​​IMI’s OncoTrack project developed colon cancer models which allow researchers to more accurately predict the effect of drugs on different types of colon cancer tumours. This and other project outputs are already helping some doctors in choosing the right drug for the right patient, and could lead to more effective treatments in the future. In an interview with the IMI Programme Office, project coordinator, David Henderson of Bayer, and academic coordinator Hans Lehrach of the Max Planck Institute for Molecular Genomics, explain why all this wouldn’t have been possible without the public-private collaboration brought by IMI.
David Henderson

‘EUPATI has been a game-changer in the empowerment of patients’ – an interview with the project coordinators

20/03/2018
EUPATI built a much-needed programme for patient involvement in medicines research and development, and has been a game changer for patient empowerment in Europe, building a movement that will long outlive the project itself. In an interview with the IMI Programme Office, project coordinator Jan Geissler of the European Patients Forum, and Matthias Gottwald of Bayer explain how patients in Europe and beyond are benefitting from the work that was done.
Jan Geissler

Faster access to better and safer medicines

05/03/2018
A potential drawback of clinical trials of new drugs is that they do not always reflect how well these will work in the 'real world'. IMI's GetReal project brought together key stakeholders to help add more such evidence into the design of trials, increasing confidence in new medicines and helping to get them to patients more quickly.
GetReal project image

European Lead Factory is leading the way to discovering new medicines

26/02/2018
IMI's European Lead Factory project has created an integrated platform which is providing an innovative range of free services, expertise and a huge collection of compounds for researchers who are developing new drugs to treat all types of human diseases.
European Lead Factory

SafeSciMET project trained more than 800 people in drug safety - an interview with project coordinators

06/02/2018
IMI’s SafeSciMET project established a much-needed education and training programme in drug safety sciences in Europe. In an interview with the IMI Programme Office, project coordinators Manfred Kansy of Roche and Nico Vermeulen of the Vrije Universiteit Amsterdam explain how this project will contribute to developing safer medicines in the future.
Pillars, illustrative

'All this wouldn’t have been possible without IMI' - an interview with Eu2P project coordinators

01/02/2018
Eu2P developed the first internationally recognised European online education & training programmes in pharmacovigilance and pharmacoepidemiology. In an interview with the IMI Programme Office, academic project coordinator Annie Fourrier-Réglat and project manager Karine Palin, both of the University of Bordeaux, reveal the long-lasting benefits that this project will bring to academia and industry.
Annie Fourrier-Réglat

‘It was a once-in-a-lifetime chance to make this happen’ – an interview with the PharmaTrain project coordinators

30/01/2018
IMI’s PharmaTrain project provided much needed harmonisation and coordination among European universities offering medicines development education and training. In an interview with the IMI Programme Office, former project coordinator Ingrid Klingmann, now president of the successor organisation, PharmaTrain Federation asbl, and Matthias Gottwald of Bayer, explain why this was an important opportunity, and why universities around the world are envious that Europe could make such a project happen.
Ingrid Klingmann

Thanks to EMTRAIN, we got out of our ivory towers – an interview with project coordinators

25/01/2018
EMTRAIN established a pan-European platform for education and training covering the whole life cycle of medicines research, from basic science through clinical development to pharmacovigilance. In an interview with the IMI Programme Office, industry co-coordinator Matthias Gottwald of Bayer and academic coordinator Michael Wolzt of the Medical University of Vienna, explain what the project achieved and how it benefitted both industry and the academic community.
Matthias Gottwald

We are more prepared for future Ebola outbreaks – an interview with the Mofina project coordinator

23/01/2018
​​​​​​​IMI’s Mofina project developed a portable device which can test for deadly Ebola in 75 minutes or less, eliminating the need to take suspected Ebola patients to treatment centres far away of their communities. In an interview with the IMI Programme office, the project’s coordinator, Edmund Newman of Public Health England, explains how Mofina’s success will save lives, and help contain future outbreaks.
Mofina device

2017

Green manufacturing for the pharmaceutical industry

11/12/2017
IMI's CHEM21 project has developed environmentally friendly chemistry processes for drug manufacturing. As well as being better for the planet, the new processes will also enable the industry to cut costs and could lead to cheaper medicines for patients.
Illustrative image

Stimulating the development of new antibiotics

08/12/2017
Many advances of modern medicine rely heavily on antibiotics - which can, however, lose their effectiveness over time as bacteria adapt. New types of these precious drugs are urgently needed. IMI's DRIVE-AB researchers are looking into ways to foster the required innovation.
Pills

Developing a fast, local test for deadly Ebola

01/12/2017
Rapid diagnosis is vital for controlling outbreaks of the deadly Ebola virus. Currently this can only be done in complex laboratories and samples from infected patients are dangerous to handle and transport. Faced with this challenge, IMI's EbolaMoDRAD project is developing fast, local tests to spot infection quickly and safely, helping to contain its spread and saving lives in the process.
blood samples

IMI projects delivering quality and quantity on publications

29/11/2017
The sheer volume and high quality of publications coming out of IMI projects is highlighted in the latest analysis of IMI publications carried out by Clarivate Analytics (formerly Thomson Reuters). IMI has been monitoring and analysing the papers coming out of its projects since 2012, and the number of publications is increasing year-on–year. In 2016 alone, IMI projects produced 796 publications, bringing the total number of publications produced by IMI...
publications

First batches of ULTRA-DD patient-based assay data released - ahead of publication

27/11/2017
The ULTRA-DD project has made good on its promise to make its data open source with the publication online of datasets from experiments on autoimmune diseases such as lupus and myositis. Through the experiments, the ULTRA-DD team has identified potential new targets that could inspire the development of new treatments for these diseases. The project hopes that if other researchers probe and use the data, they may uncover further insights...
Michael Sundström

New tumour models could lead to more effective treatments

27/11/2017
The incidence of cancer in Europe is increasing but many potential new drug treatments are found to be ineffective when tested on patients. IMI's PREDECT project has investigated new models of tumours to help researchers discover more effective treatments and boost survival rates.
breast cancer

Using health records to help clinical research

31/10/2017
New treatments must be tested in clinical trials to ensure they are safe and effective. IMI's EHR4CR project has enabled scientists to find suitable patients by searching millions of medical records while keeping personal data secure.
records illustration

New brochure: Carrying the torch for medical innovation

26/10/2017
IMI projects are accelerating the medicines development process, generating new scientific insights, and developing resources for open use by the research community. Furthermore, some of our projects are already delivering direct benefits to patients. Interested in concrete numbers and examples? Find out more about the impact and outputs of our projects in our new brochure, and learn how we are 'Carrying the torch for medical innovation'.
Cover page of the brochure

Biomarker tests to speed up cancer drug development

20/10/2017
IMI's QuIC-ConCePT project research into validating more imaging biomarkers for use in cancer drug trials seeks to speed up development of successful new drugs and avoid exposing patients to treatment that does not work for them.
CT scan

Better understanding of colon cancer to help guide treatment

28/09/2017
IMI's OncoTrack project researchers have worked to identify and characterise signs of cancer, particularly colon cancers, and patients' responses to different types of treatment. The aim is to help doctors choose the best possible treatment for an individual patient's condition, potentially improving and saving lives.
Pills

EBiSC project's stem cell biobank could lead to new drugs

19/09/2017
Europe has identified the need for a central, standardised stem cell repository providing researchers with access to quality controlled cell lines and data for future drug development. EU and industry funding helped this new biobank facility establish initial operations and create a 'foundational collection'.
Stem cell research

Mofina project develops device for faster Ebola testing

18/09/2017
IMI's Mofina project researchers have developed a portable device to test in the field whether a person has caught the deadly Ebola disease. It gives reliable results in 75 minutes, which can help contain outbreaks and save lives.
Ebola testing device

Pharma-Cog results may speed up Alzheimer’s drug development

13/09/2017
IMI’s Pharma-Cog project had an ambitious goal: to improve the success rate of Alzheimer’s disease drugs in development. As the project draws to a close, we talked to scientific coordinator Régis Bordet of the University of Lille and EFPIA project coordinator Jill Richardson of GSK. According to them, Pharma-Cog made several important contributions to this field of research, including a better understanding of the disease, and may lead to more efficient and more precise clinical trials for future drug candidates.
Jill Richardson

RAPP-ID outputs could boost development of rapid diagnostic tests

06/09/2017
The focus of RAPP-ID was the development of rapid diagnostic platforms for infectious diseases, and some of the technologies and resources developed within the project could help speed up the development of rapid diagnostic tests in the future. In an interview with the IMI Programme Office, project coordinator Jorge Villacian of Johnson & Johnson and scientific coordinator Herman Goossens of University of Antwerp, outline the challenges encountered and successes achieved.
Herman Goossens

BTCure project insights connect bone cells to rheumatoid arthritis

31/08/2017
IMI's BTCure project has generated new insights into the causes and development of rheumatoid arthritis, directing efforts towards earlier detection, prevention and the idea of inducing tolerance to this chronic and debilitating disease. Follow-up research includes new studies to further explore this 'tolerance' challenge and progress on a new antibody detecting device.
Hands of an older person

ENABLE scientists discover a new way to target drug-resistant bacteria

24/06/2017
Scientists from IMI’s ENABLE project have found a new mechanism to target drug-resistant bacteria, opening up a promising new pathway for further research. The mechanism involves DNA gyrase, a well-known enzyme that is a target of already existing antibiotics. ENABLE scientists found a new way to inhibit this enzyme and kill drug-resistant bacteria in the laboratory.
Bacteria

EPAD – revolutionising clinical trials for dementia

06/06/2017
IMI’s EPAD project has an ambitious goal – to revolutionise the way we carry out clinical trials for treatments designed to prevent Alzheimer’s dementia. In an interview with the IMI Programme Office, project coordinators Craig Ritchie of the University of Edinburgh and Serge Van der Geyten of Janssen Pharmaceutica explain what the project has achieved so far and why the project team is like a family.
Neurons in the brain

VSV-EBOVAC identifies signature of promising Ebola vaccine

10/05/2017
How exactly does our immune system respond to vaccination? In the first study of its kind, scientists from IMI’s VSV-EBOVAC project, studying a promising Ebola vaccine, set out to find out which immune cells get activated early on, which inflammatory markers are released after that, and how this early activity later impacts the production of antibodies against the Ebola virus. In the process, they discovered a unique signature of a promising Ebola vaccine candidate which could not only help predict adverse reactions and effectiveness of this vaccine, but also inform the development of vaccines for other diseases as well.
Vaccine

Of vaccines, rumours and the success of IMI’s EBODAC project

09/03/2017
When IMI’s EBODAC project started in late 2014, Ebola had already killed over 8 000 people in just a few short months, most of them in the western African nations of Liberia, Guinea and Sierra Leone. With the outbreak continuing to devastate lives across the region, fear and anxiety were rife, and rumours spread rapidly through local communities. It was against this backdrop that IMI’s EBODAC project set out to develop a community engagement strategy to enable a clinical trial of a promising new Ebola vaccine candidate. Thanks to the many innovative methods employed, including radio and drama shows, today the project celebrates its first big success: all of the adults in the trial have been successfully vaccinated. But getting there was far from easy.
The first trial participant, Idrissa Kamara, receiving his prime vaccine in Sierra Leone

'More successful than what we thought possible' – an interview with the Europain project coordinator

06/03/2017
In 2009, IMI’s Europain project set out on an ambitious path: to improve the treatment of patients with chronic pain. At the end of the project, we interviewed project coordinator Märta Segerdahl of H. Lundbeck A/S, and asked her what the project had managed to achieve. ‘We ended up more successful than we thought possible,’ she said.
Märta Segerdahl

CHEM21 method could dramatically cut production costs of essential anti-fungal medicine

01/02/2017
Scientists from the Innovative Medicines Initiative (IMI) project CHEM21 have developed a new, more efficient way of producing flucytosine, a medicine used to treat a common and often deadly fungal form of meningitis in people with HIV / AIDS. The new method, which is described in a paper in Organic Process Research & Development (OPR&D), is expected to decrease drastically costs of production, and so make the medicine more affordable for the many people with HIV / AIDS who live in low income countries. The CHEM21 team is now working to scale up the method to the industrial scale.
Drug manufacturing process

'It was a really fantastic experience' – an interview with the MARCAR project coordinator

13/01/2017
Cancer risk assessment is one of the most important steps during the development of new medicines. Launched in 2010, IMI’s MARCAR project aimed to develop early biological clues – biomarkers – which could help predict which drugs might lead to tumour growth. At the end of the project, MARCAR project coordinator, Jonathan Moggs of Novartis, spoke to the IMI programme office about the main project achievements and explained how MARCAR project outputs will make drugs safer in the future.
Jonathan Moggs

'We took the lead over US-based projects' – an interview with SUMMIT project coordinators

12/01/2017
Before SUMMIT started in 2009, ongoing research on diabetic complications in Europe was scattered amongst various countries. Fast forward six years, and Europe – by joining forces and activities - has climbed to the top of the research ladder in this field, coming close to or even surpassing similar research projects in the US. In an interview with the IMI project office, SUMMIT project coordinator Michael Mark of Boehringer-Ingelheim, and scientific coordinator Leif Groop of Lund University, explain how SUMMIT contributed to the diabetes complications field.
SUMMIT project logo

'There will be lots of benefits to patients' – an interview with the SAFE-T project coordinators

11/01/2017
SAFE-T was among the first IMI projects which started in 2009. Seven years later, the project came to a close, having achieved most of its objectives and made significant progress in developing improved tools for the prediction, detection, and monitoring of drug-induced injuries to the kidney, liver, and vascular system. In an interview with the IMI Project Office, project coordinator Michael Merz of Novartis, and scientific coordinator Thomas Joos of the Natural and Medical Institute at the University of Tübingen (NMI), share their thoughts on the project’s successes.
Michael Merz

2016

PROactive draws to a close, delivers on its promises – an interview with project coordinators

15/11/2016
PROactive was launched in 2009 with the aim of developing an innovative tool to measure physical activity in chronic obstructive pulmonary disease (COPD) patients. The project has now drawn to a close, meeting its main goal. In interview with the IMI Programme Office, PROactive’s scientific coordinator, Thierry Troosters of the University of Leuven, and project coordinator, Mario Scuri of CHIESI Pharmaceuticals, explain how the new tool works and how it will benefit patients.
Thierry Troosters

'Without IMI this would have never happened' – an interview with U-BIOPRED’s Peter Sterk

11/08/2016
U-BIOPRED was one of the first IMI projects to launch back in 2009. Now the project, which focused on severe asthma, is drawing to a close. In an interview with the IMI Programme Office, the project’s scientific coordinator, Peter Sterk of the University of Amsterdam, explains how the project has increased our understanding of severe asthma and how researchers are already using this knowledge in the development of new treatments. He also talks about how the project benefited from the involvement of patients, and how they put the concept of ‘big data’ into practice to achieve their groundbreaking results.
Peter Sterk