ReSOLUTE

Research empowerment on solute carriers
RESOLUTE logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 10
Grant agreement number
777372

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
12 000 000
EFPIA in kind
11 600 000
Other
250 000
Total Cost
23 850 000

Summary

Transport proteins are the gate-keepers of our cells, effectively controlling the flow of nutrients and other molecules across the cell membrane. With over 400 members, solute carriers represent the largest class of transport proteins. Yet although they have been implicated in diseases ranging from Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) to schizophrenia, solute carriers have never been studied in detail.

The ReSOLUTE project aims to change that, by intensifying research in, and advancing our knowledge of, the solute carrier family. Specifically, the project partners plan to deliver practical research tools, protocols, databases and platforms on solute carriers. The project’s open access ethos means the results will be of benefit to researchers in universities as well as small and large biotech companies worldwide. Ultimately, the project results will aid in the identification of solute carriers that could be used as either drug targets or as pathways for enabling the transport of medicines into specific tissues.

Achievements & News

Cache of research materials on understudied proteins now available to scientific community
December 2019

IMI’s ReSOLUTE project has made the DNA reagents for 446 solute carriers freely available in the hope that the proteins might be used as targets in drug development. Solute carriers are bound to the cellular membrane and transport nutrients, like vitamins, sugars, and drugs. ###However, despite being the second biggest family of membrane proteins in the human genome, and despite being implicated in diseases, such as schizophrenia, ALS, Alzheimer’s, diabetes and cancer, there is still a great deal that we do not know about them. One of the objectives of the ReSOLUTE project is to generate reagents that would allow the scientific community to work more efficiently with this family of proteins and, hopefully, make use of them as targets for drug development.

‘Now, the consortium has made available the DNA sequence of approximately 400 solute carriers. The DNA has been codon-optimised, which basically means to improve the sequence to make it easier for the cells to produce higher amounts of it. This is useful when scientists want to study these proteins in the laboratory. You might want to study what they transport, their biochemical and biophysical properties, or to purify them to determine their 3D structures,' said the project in an interview with the IMI Programme Office. The DNA sequences are available at Addgene.org, which is a not-for-profit repository for this kind of reagents. Addgene sends the reagents on ReSOLUTE’s behalf for a small fee, which covers quality control and shipping costs. Any interested laboratory can order them directly from the Addgene website. In the few weeks that the material has been available, several labs worldwide have already requested the plasmids.

Read more

RESOLUTE releases Knowledge Base on solute carrier proteins
September 2019

IMI’s RESOLUTE project has published the RESOLUTE Knowledge Base, an online database that brings together in one place information on a group of proteins called solute carriers (SLCs). ###SLCs are transport proteins that play an important role in controlling what molecules are allowed into and out of our cells. Although they have been implicated in diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS) and schizophrenia, SLCs have not yet been studied in detail. RESOLUTE aims to change that. Currently, the Knowledge Base, which is freely accessible to the scientific community, comprises high quality, reliable information from publicly available sources. ‘Public domain data on SLCs from multiple sources is compiled, connected and integrated, allowing SLC researchers to rapidly get an overview on the current knowledge on any human SLC transporter,’ explains Professor Giulio Superti-Furga, RESOLUTE academic coordinator from CeMM - the Research Center for Molecular Medicine of the Austrian Academy of Sciences. ‘This is a new milestone achieved by the RESOLUTE consortium and it is our first pillar to foster research on solute carriers. It will also allow RESOLUTE to become a reference hub for SLC research and open knowledge worldwide.’ In the coming years, RESOLUTE will add further information to the Knowledge Base from public resources as well as data generated by the project. RESOLUTE is due to end in 2023, but CeMM has committed to maintaining the Knowledge Base for a further 5 years after the end of the project.

Participants Show participants on map

EFPIA companies
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • Novartis Pharma AG, Basel, Switzerland
  • Pfizer Limited, Sandwich, Kent , United Kingdom
  • Sanofi-Aventis Recherche & Developpement, Chilly Mazarin, France
  • Vifor (International) AG, St. Gallen, Switzerland
Universities, research organisations, public bodies, non-profit groups
  • Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Ev, Munich, Germany
  • The University Of Liverpool, Liverpool, United Kingdom
  • Universitat Wien, Vienna, Austria
  • Universiteit Leiden, Leiden, Netherlands
  • University of Oxford, Oxford, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Axxam S.A, Bresso (Milan), Italy
  • Cemm - Forschungszentrum Fuer Molekulare Medizin GMBH, Vienna, Austria
Project leader
Claire M. Steppan
Pfizer