TRIC-TB

Boosting Ethionamide efficacy and lowering the dose with a small molecule transcriptional modulators, to overcoming MDR-TB infections and define a new place for Ethionamide in 1st-line TB treatments
TRIC-TB logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 16
Grant agreement number
853800

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
6 926 375
EFPIA in kind
1 417 500
Other
29 375
Total Cost
8 373 250

Summary

Tuberculosis is a major public health threat. In 2017 alone, over 10 million people developed active TB and it killed 1.7 million, making it one of the top 10 causes of death worldwide. Treatment is via a six-month course of four antibiotics. Drug resistance is a major issue in TB – in 2017, over half a million drug-resistant cases were recorded, and most of these (82 %) were multi-drug resistant (MDR); these cases are much harder to treat successfully.

The aim of TRIC-TB is to advance the development of two molecules that could boost the infection-fighting ability of the anti-TB drug Ethionamide. The compounds, BVL-GSK038 and BVL-GSK098, work by interfering with the systems that control gene activity in the TB bacteria. Previous studies have shown that they are able to boost the efficacy of Ethionamide three-fold.

If the results are confirmed in humans, this could allow doctors to reduce the dose of Ethionamide typically given to patients, something that would also reduce the side effects associated with the drug. Moreover, it appears that BVL-GSK038 and BVL-GSK098 overcome some of the mechanisms that the TB bug has developed against Ethionamide.

TRIC-TB will carry out further research in areas such as safety, mechanism of action, and potential synergies with other drugs; if these go well, the team will carry out the first clinical studies in humans of these potential drugs.

Ultimately, the information delivered from this research will hopefully allow the new compounds to be integrated into new, improved regimens to treat TB, including MDR-TB.

TRIC-TB is part of the IMI AMR Accelerator Programme.

Achievements & News

Regulatory decision gives boost to development of potential new TB drug
July 2020

A decision by US regulators is set to speed up reviews of a potential new TB drug being developed by IMI’s TRIC-TB project.###

Tuberculosis is a major public health threat. In 2017 alone, over 10 million people developed active TB and it killed 1.7 million, making it one of the top 10 causes of death worldwide. Treatment is via a six-month course of four antibiotics.

IMI’s TRIC-TB project was set up to advance the development of molecules that could boost the infection-fighting ability of the anti-TB drug Ethionamide. Now, the US Food and Drug Administration (FDA) has given Qualified Infectious Disease Product (QIDP) designation to one of the compounds (BVL-GSK098) in a fixed combination with Ethionamide for the treatment of pulmonary TB.

QIDP designation is given to antibacterial or antifungal drugs designed to treat serious or life-threatening infections. Crucially, QIDPs are eligible for priority and fast track review by the FDA. This will therefore help TRIC-TB to speed up the development of the compound.

Ultimately, if clinical trials are successful, BVL-GSK098 could allow doctors to reduce the dose of Ethionamide typically given to patients, something that would also reduce the side effects associated with the drug.

Find out more

Participants Show participants on map

EFPIA companies
  • Glaxosmithkline Investigacion Y Desarrollo SL, Tres Cantos, Spain
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Bioversys AG, Basel, Switzerland
Third parties
  • BioVersys SAS, Lille, France
Project coordinator
Jonathan Butcher
Bioversys AG