Skip to main content

Rapid evolution and host immunity drive antibiotic resistance in acute infection

COMBACTE-MAGNET have added to our understanding of how resistance emerges during infection

Image by PongMoji via Shutterstock
Image by PongMoji via Shutterstock


It is known that treating patients with antibiotics is associated with the emergence of resistance - and worse outcomes for patients. But how resistance emerges during infections remains poorly understood.

A new study published in Nature Communications reports that rapid bacterial evolution interacts with host immunity to shape both the rise, and fall, of resistance during infection. This study was performed by the University of Oxford in collaboration with the University of Antwerp, University Hospital Son Espases and AstraZeneca as part of the IMI COMBACTE-MAGNET consortium.

The consortium is a collaboration between academia and industry professionals aiming to find new approaches to combat antibiotic resistance. This study highlights the need to understand better how our immune system works with antibiotics to suppress bacterial infections.

The research described in this article is part of a larger ASPIRE-ICU study, which stands for Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE – Intensive Care Units.

The ASPIRE-ICU trial was conducted by the COMBACTE consortium and brought together multiple collaborators from leading academic research labs along with AstraZeneca scientists.

This article originally appeared on the website of the COMBACTE project. 


Related projects: 

Manage your newsletter subscriptions
Stay informed - subscribe to our newsletter.