Translational quantitative systems toxicology to improve the understanding of the safety of medicines
TransQST logo


Start Date
End Date
IMI2 - Call 6
Grant agreement number

Type of Action: 
RIA (Research and Innovation Action)

IMI Funding
8 000 000
EFPIA in kind
9 327 874
Total Cost
17 327 874


When developing a new medicine, determining whether or not it will be safe for patients to take remains a challenge, and adverse drug reactions (ADRs) remain a major issue for clinicians. Of particular concern is damage to vital organs such as the liver, kidney, cardiovascular and gastrointestinal systems. The TransQST project will gather together data (both new and existing) and develop tools that will make it easier to assess the safety profile of potential medicines. They will also work to add to our understanding of when results in animal tests can be reliably extrapolated to humans, and develop models to predict concentrations of medicines in tissues, an important element of safety assessments. Another project output will be improved methods to visualise and analyse complex datasets during decision making on drug safety.

Participants Show participants on map

EFPIA companies
  • Abbvie Deutschland GMBH & Co Kg, Wiesbaden, Germany
  • Astrazeneca AB, Södertälje, Sweden
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • Eli Lilly and Company Limited, Basingstoke, United Kingdom
  • Glaxosmithkline Research And Development LTD., Brentford, Middlesex, United Kingdom
  • Institut De Recherches Internationales Servier, Suresnes, France
  • Janssen Pharmaceutica Nv, Beerse, Belgium
  • Orion Oyj, Espoo, Finland
  • Sanofi-Aventis Recherche & Developpement, Chilly Mazarin, France
Universities, research organisations, public bodies, non-profit groups
  • Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
  • European Molecular Biology Laboratory, Heidelberg, Germany
  • Forschungsgesellschaft Fur Arbeitsphysiologie Und Arbeitsschutz E.V., Dortmund, Germany
  • Fundacio Institut Mar D Investigacions Mediques Imim, Barcelona, Spain
  • The University Of Liverpool, Liverpool, United Kingdom
  • Universitat Wien, Vienna, Austria
  • Universitatsklinikum Heidelberg, Heidelberg, Germany
  • Universiteit Leiden, Leiden, Netherlands
  • Universiteit Maastricht, Maastricht, Netherlands
  • University of Oxford, Oxford, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Certara Uk Limited, London, United Kingdom
  • Ocello BV, Leiden, Netherlands
  • Synapse Research Management Partners SL, Barcelona, Spain
Project coordinator
Rso Eu
The University Of Liverpool
Project contact
Project leader
Loic Laplanche