RealHOPE

Real world handling of protein drugs - exploration, evaluation and education
RealHOPE logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 20
Grant agreement number
101007939

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
3 139 984
EFPIA in kind
3 959 000
Total Cost
7 098 984

Summary

Many new medicines are based on proteins, and these have dramatically improved the lives of people with a range of diseases. However, ensuring the quality of protein drug products, particularly after manufacture, is far from easy. Proteins can be affected by exposure to heat, sunlight or shaking. If stored or handled inappropriately during transport, or at the hospital, pharmacy or patient’s home, the proteins can break down, compromising the safety and efficacy of the product. RealHOPE aims to deliver knowledge and tools to address this issue.

One major project goal is to improve our understanding of how protein drugs are handled in the real world, and the effect this has on product quality. To do this, the project will use smart tag technologies to log light, temperature and shock during real-life protein handling. They will also analyse the proteins at different stages. The data gathered will be used to identify the level and type of protein degradation triggered by different aspects of handling. The project team will also interview people who work in pharmacies and clinics as well as patients and carers to understand how they currently handle protein drugs and what limitations they face.

The project will use the data from these studies to develop teaching materials, including apps, for different target groups, namely hospital pharmacists, nurses, patients, and care givers.

Ultimately, RealHOPE will aid in the development of more robust, safer protein drugs.

Participants Show participants on map

EFPIA companies
  • Abbvie Inc, North Chicago, Illinois, United States
  • Astrazeneca AB, Södertälje, Sweden
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • F. Hoffmann-La Roche AG, Basel, Switzerland
  • Lonza AG, Basel, Switzerland
  • Merck Kommanditgesellschaft Auf Aktien, Darmstadt, Germany
  • Pfizer Limited, Sandwich, Kent , United Kingdom
  • Sanofi-Aventis Deutschland GMBH, Frankfurt / Main, Germany
  • Teva Pharmaceutical Industries Limited, Netanya, Israel
Universities, research organisations, public bodies, non-profit groups
  • Azienda Ospedaliera Universitaria Integrata 'Istituti Ospitalieri Di Verona, Verona, Italy
  • Azienda Ulss N3 Serenissima, Venezia Mestre, Italy
  • Centre For Process Innovation Limited Lbg, Redcar Cleveland, United Kingdom
  • Fundacio Clinic Per A La Recerca Biomedica, Barcelona, Spain
  • Lunds Universitet, Lund, Sweden
  • Region Uppsala, Uppsala, Sweden
  • Rise Research Institutes Of Sweden AB, Stockholm, Sweden
  • Societa Italiana Di Farmacia Clinica E Terapia, milano, Italy
  • Universita Degli Studi Di Padova, Padova, Italy
  • University College London, London, United Kingdom
  • University Of Dundee, Dundee, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Elsa Science AB, Stockholm, Sweden
  • Plurima S.A, Milano, Italy
  • Probation Labs Sweden AB, Malmö, Sweden
Patient organisations
  • Reumatikerforbundet, Stockholm, Sweden
Third parties
  • Hospital Clinic De Barcelona, Barcelona, Spain
Project coordinator
Marie Wahlgren
Lunds Universitet