Antimicrobial resistance (AMR) is a major threat to human and animal health worldwide. Vaccines and monoclonal antibodies (mAbs, laboratory-made antibodies similar to those your body makes in response to an infection) could play a key role in the fight against AMR. Developing vaccines and mAbs is costly and time-consuming, and so choices need to be made on which vaccines / mAbs should be prioritised for development. However, there are many drug-resistant infections and potential vaccines and mAbs out there, and right now it is very difficult to determine which vaccines / mAbs would have the greatest impact on the burden of AMR and which would only have a limited impact.
The aim of PRIMAVERA is to develop mathematical models and an epidemiological repository that will facilitate the assessment of different vaccines and mAbs in terms of their likely impact on AMR.
PRIMAVERA will set up an open access, web-based platform that will allow the wider scientific and healthcare communities to freely access and use the models and repository. For example, policy makers and healthcare authorities could use the platform to make informed decisions on which vaccines and mAbs should be prioritised. A project sustainability plan will ensure long-term access to the project results, including the models, once the project has finished.
PRIMAVERA is part of the AMR Accelerator Programme.