Impentri

Development of Impentri, an intravenous imatinib formulation for COVID-19 acute respiratory distress syndrome (ARDS)
Impentri logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 21
Grant agreement number
101005142

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
3 662 963
Other
322 769
Total Cost
3 985 732

Summary

Many people with severe COVID-19 infection experience a build-up of fluid in the lungs, making it hard to breathe and, in the worst cases, contributing to the death of the patient. The body’s own immune response is partly responsible for this build-up of fluid.

There are signs that the generic drug imatinib, which is used to treat certain cancers including some forms of leukaemia, could address the problem. The goal of Impentri is to carry out clinical trials to get solid data on its efficacy and safety as a treatment for COVID-19 patients with a build-up of fluid on the lungs.

The project will run a multi-centre, randomised, double-blind clinical trial involving 100 patients in intensive care. All patients will be monitored for oxygen levels, fluid balance, length of stay and other clinical outcomes.

The project has already received scientific advice from the European Medicines Agency (EMA) for the treatment of acute respiratory distress syndrome. The EMA has also granted orphan drug status.

Achievements & News

Participants Show participants on map

Universities, research organisations, public bodies, non-profit groups
  • Academisch Medisch Centrum Bij De Universiteit Van Amsterdam, Amsterdam, Netherlands
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Exvastat LTD, Cambridge, United Kingdom
  • K.A.B.S. Laboratories Inc. - Kabs, St-Hubert, Canada
  • Orion Sante SARL, Le Plesiss Robinson, France
  • Stichting Vumc, Amsterdam, Netherlands
Project coordinator
David Cavalla
Exvastat LTD