IMI’s GETREAL project delivered a range of new tools and resources for incorporating real-life data earlier into drug development and decision making processes. The aim of the GETREAL Initiative is to drive the adoption of these tools and so increase the quality of real-world evidence (RWE) generation in medicines development and regulatory /health technology assessment processes. Specifically, the project will set up a think tank comprising international thought leaders to discuss, assess and give recommendations on opportunities and barriers to the generation, use and acceptability of RWE. The members will also act as ambassadors for the use of RWE, engaging with key stakeholder groups to facilitate the uptake of the project outputs. The project will also set up a number of task forces to drive the development of specific GETREAL outputs in the areas of pragmatic trials; network meta-analysis and benefit-risk assessment; and statistical approaches for enriching clinical trials with real world data. Finally, the project will create a RWE research community including researchers with expertise in RWE generation as well as regulators, health technology assessment (HTA) bodies, physicians and patients. The community will provide feedback on guidelines, recommendations and white papers produced by the project.