BIOMAP

Biomarkers in atopic dermatitis and psoriasis
BIOMAP logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 13
Grant agreement number
821511

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
10 500 000
EFPIA in kind
10 684 847
Total Cost
21 184 847

Summary

Atopic dermatitis and psoriasis are serious skin diseases that affect over 300 million people globally. Atopic dermatitis causes itchy, inflamed skin that can become blistered, while psoriasis is characterised by red, scaly plaques on the skin. For many patients, the treatments available do not work well and the diseases place a huge burden on patients, their families, and healthcare systems. BIOMAP aims to shed new light on the underlying causes of both diseases, as well as the genetic and environmental factors that influence how a patient’s disease will progress and how well they will respond to a given treatment. They will do this by studying in depth data and samples from 50 000 patients as well as healthy individuals. Ultimately, BIOMAP hopes to identify new sub-types of the diseases that will allow clinicians and patients to make better, more personalised decisions on treatments. To ensure patients’ views are integrated into the project, BIOMAP has set up a Patient Advisory Group.

Achievements & News

Unprecedented study of inflammatory skin disease data gets underway
June 2020

Despite a relatively good choice of treatment options for inflammatory skin diseases like psoriasis and atopic dermatitis, finding a drug that definitely works in a given patient is still very much trial and error. The BIOMAP project, which launched in 2019, will carry out the biggest study yet of the molecular drivers of inflammatory skin diseases, with particular focus on psoriasis and atopic dermatitis, in an effort to uncover tell-tale biomarkers that will help predict the course of the disease, and the response to therapy. ###As a first step, BIOMAP is bringing together data from previous and ongoing clinical studies to create a large data platform capable of delivering sound results.

Having spent the first year of the project making sure their data collections adhere to stringent rules governing patient data privacy, the project partners have now started uploading the datasets to their central data platform.

‘The datasets are being harmonised according to what we call our ‘glossary’, so that the nomenclature and phrasing is the same across all cohorts, and that key information is available from all of them,’ says project coordinator Stephan Weidinger of the University Hospital in Kiel, Germany. He gives a simple example to illustrate why this is necessary: ‘It starts with the disease name itself. In some studies, the disease is called ‘atopic dermatitis’, and in other studies, it’s ‘atopic eczema’. And then there are studies where is called just ‘eczema’.’ The diagnostic criteria can also vary from study to study. ‘So, we have to check that and make it clear what criteria has been used and to which degree it is comparable.’

Find out more

Participants Show participants on map

EFPIA companies
  • Boehringer Ingelheim Internationalgmbh, Ingelheim, Germany
  • Leo Pharma As, Ballerup, Denmark
  • Novartis Pharma AG, Basel, Switzerland
  • Pfizer Limited, Sandwich, Kent , United Kingdom
  • Sanofi-Aventis Deutschland GMBH, Frankfurt / Main, Germany
  • UCB Biopharma SRL, Brussels, Belgium
Universities, research organisations, public bodies, non-profit groups
  • Academisch Medisch Centrum Bij De Universiteit Van Amsterdam, Amsterdam, Netherlands
  • Academisch Ziekenhuis Leiden, Leiden, Netherlands
  • Ait Austrian Institute Of Technology GMBH, Wien, Austria
  • Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • Christian-Albrechts-Universitaet Zu Kiel, Kiel, Germany
  • Den Selvejende Institution Dansk Borneastma Center, Gentofte, Denmark
  • HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v., Villingen, Germany
  • Heinrich-Heine-Universitaet Duesseldorf, Düsseldorf, Germany
  • Itä-Suomen yliopisto, Kuopio, Finland
  • Karolinska Institutet, Stockholm, Sweden
  • King'S College London, London, United Kingdom
  • Klinikum Rechts Der Isar Der Technischen Universitat Munchen, Muenchen, Germany
  • Kobenhavns Universitet, Copenhagen, Denmark
  • London School Of Hygiene And Tropical Medicine Royal Charter, London, United Kingdom
  • Stichting Katholieke Universiteit, Nijmegen, Netherlands
  • Tampereen Korkeakoulusaatio Sr, Tampere, Finland
  • Tampereen Yliopisto, Tampere, Finland
  • Tartu Ulikool, Tartu, Estonia
  • Technische Universitaet Muenchen, Muenchen, Germany
  • Trinity College Dublin, Dublin, Ireland
  • Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Universitat Wien, Vienna, Austria
  • Universite Du Luxembourg, Esch-sur-Alzette, Luxembourg
  • University Of Bristol, Bristol, United Kingdom
  • University Of Dundee, Dundee, United Kingdom
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • Eurice European Research And Project Office GMBH, Saarbrücken, Germany
  • Information Technology For Translational Medicine (Ittm) SA, Esch-sur-Alzette, Luxembourg
Project coordinator
Stephan Weidinger
Christian-Albrechts-Universitaet Zu Kiel