eTRIKS

Delivering European Translational Information & Knowledge Management Services
Delivering European Translational Information & Knowledge Management Services

FACTS & FIGURES

Start Date
End Date
Call
IMI1 - Call 4
Grant agreement number
115446

Contributions
IMI Funding
10 309 818
EFPIA in kind
10 795 178
Other
2 680 745
Total Cost23 785 741

Summary

Many IMI projects involve the integration of data from different sources, and until now every project has had to devise its own solutions to the problems raised by data sharing. Enter eTRIKS, which aims to create and run an open, sustainable research informatics and analytics platform for use by IMI (and other) projects with knowledge management needs. In addition, the project partners will provide associated support, expertise and services to ensure users gain the maximum benefit from the platform.

Reducing redundancy

By the beginning of 2012, IMI had launched 30 projects, many of which involve the integration and analysis of diverse types of biological and medical data from a range of sources. This approach helps to speed up and improve drug discovery by allowing researchers to uncover new insights into disease progression and drug safety and efficacy for example. However, merging and managing all this data is far from easy. IMI’s first Strategic Research Agenda highlighted the need for a common knowledge management platform for IMI projects, but until now this has not been set up.

As a result, each project has had to invest in its own knowledge management system, resulting in considerable duplication of efforts and raising the risk that data will be lost when the project ends. Furthermore, to date there has been no agreed knowledge platform technology that could be used to build such a common service.

Enter eTRIKS

eTRIKS aims to deliver an open, sustainable translational research informatics / knowledge management platform based on agreed standards. The starting point of the project will be tranSMART, an open source platform that is already being applied successfully in IMI’s severe asthma project U-BIOPRED. The eTRIKS team will provide a suite of support services covering the whole translational research project life cycle, including business analysis, platform development, curation and hosting support, standards development, and ethics consultation.

Significant savings

By creating a single, open source platform that meets industry needs while remaining affordable for public partners, eTRIKS will deliver considerable cost savings for public private partnerships that use it. Furthermore, by ensuring the consistent implementation of format and content standards, eTRIKS will facilitate the reuse of data (with appropriate governance) to study new issues and speed up the development of new drugs for patients.

In the longer term, the project plans to develop a business model that will allow the platform to continue to operate after the initial IMI funding period. The partners also hope that their work will result in the formation of an active international translational research analytics and informatics community.

Achievements & News

Join eTRIKS for the Bioinformatics and Translational Research 2017 meeting
IMI’s eTRIKS project will hold a meeting on bioinformatics and translational research in Barcelona, Spain on 15-16 May 2017. ###The datasets that are generated today are complex, and involve many different types of data. The consequence is that the integration of multiple types expertise is necessary. Over the last 4 years, the eTRIKS project has helped 41 translational research projects to get more value out of their data. During that time, it has become apparent that many scientists are simply not aware about the data infrastructure that is available for translational research. With that in mind, the two main themes of the meeting are:
 - understanding the landscape of bioinformatics infrastructure and how to reduce fragmentation;
 - giving translational researchers the knowledge and the tools they need to collaborate on making sense of translational research data faster.
At the event, data scientists and translational researchers will work together to build a common understanding of today’s research data challenges. The aim is to find ways to help fulfil the promise of better health through the optimal use of data. The event will therefore be of significant value to anyone involved in research data or in developing tools to manage research data.
Registration is free via the event webpage
(February 2017)
 

eTRIKS inspires a spin-off for scientific data analysis
IMI projects not only deliver great results, but sometimes also inspire the creation of spin-off projects, providing indirect economic benefits. The latest proof of that is ITTM (Information Technology for Translational Medicine, S.A.), a Luxembourg company, ###which was built on the knowledge and expertise gained during the eTRIKS project. While working on eTRIKS, researchers from the University of Luxembourg realised that there is really high demand for cleaning, filtering, hosting and standardising data in the pharmaceutical sector. Those services were outside the scope of the eTRIKS project which mainly focuses on providing an open source platform for knowledge management. So, the Luxembourg partners involved in the project started a new company, ITTM. ‘The expertise we gained during eTRIKS regarding curation and standardisation of data are the building blocks of ITTM’s service offers,’ said Reinhard Schneider, Head of the Bioinformatics Core facility at the University of Luxembourg’s Centre for Systems Biomedicine. ‘In addition we were lucky to get the POST group of Luxembourg as a strategic investor. They own big very secure data centres, which gives ITTM a very professional hosting infrastructure.’ (October 2016)

Luxembourg joins ELIXIR, sustainability of eTRIKS ensured
IMI projects gather vast amounts of data during their lifespan, and once they end, there is usually the question – how to ensure that this data becomes available to the public, benefiting society in the long run? Thanks to the work of the Luxembourg Centre of Systems Biomedicine (LCSB)### at the University of Luxembourg and their involvement in IMI’s eTRIKS project, now there is a solution. The LCSB, one of eTRIKS project partners, was appointed by the Luxembourg state to host the latest node of ELIXIR, a European network for the sharing of scientific data. While eTRIKS provides projects with an open-source platform for knowledge management, ELIXIR provides an infrastructure, a kind of a highway system, which integrates research data from all corners of Europe and ensures a seamless service provision that is easily accessible to all. Luxembourg is the newest member in a network of 18 European countries and they are also the first node of ELIXIR, which will become a data repository for translational research, the interdisciplinary branch of the biomedical field. The inspiration to specialise in translational data came from IMI’s eTRIKS project, said Reinhard Schneider, Head of the Bioinformatics Core facility at the University of Luxembourg’s Centre for Systems Biomedicine, who is also involved in eTRIKS. 'The sustainability of eTRIKS is now secured,' he added. 'All IMI projects which will open their data are welcome to deposit their data on the Luxembourg ELIXIR node.' (July 2016)

eTRIKS provides practical advice on data standards
IMI’s knowledge management project eTRIKS has created a ‘standards starter pack’ to raise awareness of, and provide guidance on, data standards in clinical, genomic and translational data management. ### Data standards are vital tools in data management, as they make it easier to load data into knowledge management platforms and compare it to other datasets that have applied the same standards. Until now, information on standardisation was fragmented; the new starter pack provides a comprehensive, easy to navigate map of standardisation efforts. As such, it is designed primarily for data managers, data curators and scientists concerned with the long term impact and visibility, reproducibility, reuseability of their work. The landscape of data standardisation is constantly evolving, as new techniques are developed and new therapeutic areas covered. For this reason, eTRIKS aims to release twice-yearly updates of its starter pack. Furthermore, the team is working on companion documents as well as curation support tools to facilitate implementation of the recommended standards. Meanwhile, eTRIKS is keen to receive feedback on the current version of the standards starter pack.

Join eTRIKS in Amsterdam for its community meeting
IMI data management project eTRIKS will hold a community meeting in Amsterdam on 22 October. The event represents an excellent opportunity to learn about the eTRIKS project and the services it offers to IMI and other projects. A highlight of the event will be a review of how eTRIKS works with the IMI project ABIRISK. ### ABIRISK’s goal is to enhance our understanding of safety issues surrounding medicines based on biological molecules such as proteins and monoclonal antibodies. eTRIKS has set up a specific tranSMART tool for ABIRISK partners, onto which ABIRISK data has been curated, uploaded, stored and analysed. The meeting will also mark the launch of the eTRIKS Labs, an online space where new projects will be made available for review and feedback. According to the project, eTRIKS Labs will make it easier to co-create tools, services, training and guidelines for translational research.
 - Register here 
(September 2015)

IMI projects working together – eTRIKS gives U-BIOPRED boost
Severe asthma is often difficult to manage and many patients are unresponsive to treatment. IMI’s U-BIOPRED project aims to make severe asthma diagnosis and treatment more personalised by creating ‘handprints’ that identify sub-phenotypes of asthma. The eTRIKS project has been working with U-BIOPRED by deploying analytical techniques ###to help them in their research, in order to create an environment where the diverse ‘big data’ sets can be compared and analysed. “eTRIKS provides gel without which we could be floating in pools of excess data with no direction,” said Professor Ian Adcock at Imperial College. “U-BIOPRED is using these data to produce at least 60 publications to advance the understanding of the complex causes and subtypes of severe asthma. The eTRIKS/tranSMART platform is a key ingredient to making this happen.” Read the press release. (June 2015)

Take advantage of the eTRIKS data curation service
IMI’s eTRIKS project is inviting IMI and other projects to use its data curation services for public studies. eTRIKS’s goal is to promote the effective management and sharing of translational research information for IMI projects. ###Public data repositories provide access to large amounts of data, but getting full value from them can be difficult. eTRIKS uses the open source tranSMART toolto provide access to different types of biological and clinical data in a well-structured environment. The project places a special emphasis on data cleaning and standardisation to deliver high data quality and improve cross-study compatibility.
-Learn more about the eTRIKS curation services
-Projects can submit public data curation requests via this form
-For more information on how tranSMART works, watch this video
(July 2014) 

eTRIKS' first community meeting
IMI’s eTRIKS project held its first community meeting entitled Translational Research Knowledge Management in Action in Barcelona, Spain on 31 January 2014. ###
Ewan Birney of the European Bioinformatics Institute (EBI) gave the keynote speech on EMBL-EBI and Elixir: the importance of a life science data infrastructure. The agenda also included presentations on the challenges faced and solutions from projects supported by eTRIKS, as well as the launch of the eTRIKS public server and platform 1.1.1. 
   - To stay up to date with eTRIKS, sign up to their blog and newsletter
(November 2013)

Transforming tranSMART: eTRIKS vision for knowledge management platform takes shape
IMI project eTRIKS is making progress towards its goal of turning the tranSMART knowledge management and analysis platform into an open system that ###can be readily adapted to diverse translational research needs. At a recent workshop, 40 people from 12 organisations reviewed the state of the art in the area and set out a roadmap for the development of the platform. Describing tranSMART as ‘a great opportunity for all stakeholders’, eTRIKS academic lead Yi-Ke Guo of Imperial College London said: ‘We are in the midst of a transition from a vender-owned, pharmaceutical company centric application to an open platform centred on the common needs of all translational research stakeholders.’ The key decision coming out of the meeting was the revision of the core of transMART into a set of pluggable components or ‘legos’. This will allow different projects and users to configure tranSMART to fit their needs.
   -   More information on the workshop can be found in an eTRIKS blog post.
   -   Sign up to receive the latest updates on the project by filling in the form to the right of the blog text.
(March 2013)


eTRIKS launches new version of TransMART knowledge management system
IMI’s eTRIKS project has launched a new version of its open, sustainable translational research informatics / knowledge management platform TransMART. ###The update is important because it includes the replacement of a proprietary component with an open source component, and so will allow the project to build on inputs from the wider development community. Using open source software instead of proprietary software will result in savings of some €350 000 in licensing fees over five years for projects using eTRIKS’s services. Elsewhere, the project has already delivered three webinars on TransMART and launched a LinkedIn group to provide updates on the project’s activities and encourage debates on issues relating to data and knowledge management.
(February 2013)

Participants Show participants on map

EFPIA companies
  • AstraZeneca AB, Södertälje, Sweden
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Eli Lilly and Company Ltd, Basingstoke, United Kingdom
  • F. Hoffmann-La Roche Ltd, Basel, Switzerland
  • Glaxosmithkline Research And Development LTD, Brentford, Middlesex, United Kingdom
  • H. Lundbeck A/S, Valby, Denmark
  • Janssen Pharmaceutica NV, Beerse, Belgium
  • Merck KGaA, Darmstadt, Germany
  • Pfizer Limited, Sandwich, Kent , United Kingdom
  • Sanofi-Aventis Research and Development, Chilly Mazarin, France
Universities, research organisations, public bodies, non-profit groups
  • Association Eisbm, Vourles, France
  • CDISC Europe Foundation, Brussels, Belgium
  • Centre National De La Recherche Scientifique, Paris, France
  • Imperial College of Science, Technology and Medicine, London, United Kingdom
  • Universite Du Luxembourg, Esch-sur-Alzette, Luxembourg
  • University of Oxford, Oxford, United Kingdom
Small and medium-sized enterprises (SMEs)
  • BioSci Consulting, Maasmechelen, Belgium
Non EFPIA companies
  • ID Business Solutions Limited, Guildford, United Kingdom

CONTACT

Project coordinator
Eva Lindgren
AstraZeneca AB
Eva.Lindgren[at]astrazeneca.com
Managing entity
Yike Guo
Imperial College of Science, Technology and Medicine
y.guo[at]imperial.ac.uk