BigData@Heart logo


Start Date
End Date
Grant agreement number

IMI Funding
9 664 970
EFPIA in kind
9 734 000
Total Cost19 398 970


Cardiovascular disease (CVD) is a major killer in Europe, causing 3.9 million deaths (around 45% of all deaths) annually. What’s more, a third of deaths from CVD occur in the under 75s. On the economic front, CVD costs the EU around EUR 210 billion a year, with healthcare costs accounting for just over half of this figure. Three diseases – atrial fibrillation (AF), heart failure (HF) and acute coronary syndrome (ACS) are major drivers of CVD. All three are extremely complex and characterised by large differences between patients with the same diagnosis. As a result, it is hard to predict which patients will respond best to which treatments.

The BigData@Heart project is part of IMI’s Big Data for Better Outcome (BD4BO) Programme. It brings together some of Europe’s leading experts in CVD treatment and management, as well as epidemiologists, big data scientists, doctors, industry representatives, patient representatives, and ethics and legal experts. Between them, the partners have access to many cohorts and databases in this field. With this diverse team and resources, the project will be able to develop new definitions of diseases and outcomes; informatics platforms that link, visualise and harmonise different data sources; data science techniques; and guidelines on the cross-border use of big data resources. In the long term, the project expects to have an impact on our understanding of heart disease, the discovery of new targets for treatments, and progress towards personalised treatments for CVD.

Participants Show participants on map

EFPIA companies
  • Bayer Aktiengesellschaft, Leverkusen, Germany
  • Institut De Recherches Internationales Servier, Suresnes, France
  • Novartis Pharma AG, Basel, Switzerland
Universities, research organisations, public bodies, non-profit groups
  • Charité – Universitätsmedizin Berlin, Berlin, Germany
  • European Heart Network , Bruxelles, Netherlands
  • Fundación para la investigación del Hospital Clinico de la Comunidad Valenciana , Valencia, Spain
  • International Consortium for Health Outcomes Measurement Inc, Cambridge, United States
  • Karolinska Institutet, Stockholm, Sweden
  • Societe Europeenne De Cardiologie, Biot, France
  • Stichting MLC Foundation, Den Haag, Netherlands
  • Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
  • Universitair Medisch Centrum Utrecht , Utrecht, Netherlands
  • University College London, London, United Kingdom
  • University of Birmingham, Birmingham, United Kingdom
  • University of Cambridge, Cambridge, United Kingdom
  • Uppsala universitet, Uppsala, Sweden
  • Vifor (International) AG, St. Gallen, Switzerland
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • SomaLogic, Inc., Boulder, United States
  • The Hyve B.V., Utrecht, Netherlands
Third parties
  • International Consortium for Health Outcomes Measurement Ltd, London, United Kingdom


Project coordinator
Diederick Grobbee
Universitair Medisch Centrum Utrecht