ZAPI

Zoonotic anticipation and preparedness initiative
Ongoing | IMI1 |
ZAPI Zoonotic anticipation and preparedness initiative

FACTS & FIGURES

Start Date
End Date
Call
IMI1 - Call 11
Grant agreement number
115760

Type of Action: 
RIA (Research and Innovation Action)

Contributions
IMI Funding
9 538 688
EFPIA in kind
9 875 000
Other
2 966 475
Total Cost
22 380 163

Summary

Many infectious diseases, including influenza and Ebola, can be transmitted to humans from animals (and vice-versa). Known as zoonoses, these diseases represent a serious threat to both human and animal health. ZAPI brings together experts in human and animal health to create new platforms and technologies that will facilitate a fast, coordinated, and practical response to new infectious diseases as soon as they emerge.

25 outbreaks in 20 years 

New infectious diseases are emerging at an increasing frequency in the EU and other regions of the world, with the potential to profoundly impact public and animal health, and strongly disrupt local and international economies. The majority of these diseases are zoonoses, meaning they originate in or are transmitted by animals. In the last 20 years, there have been 25 documented emerging diseases that moved from wild or domestic animals to human populations. It is highly probable that zoonoses that spread rapidly (many of them are insect-borne diseases) in one or several EU countries will continue or increase due to environmental and demographic changes. The EU has already been affected by many zoonoses over the past 20 years, for example, West Nile virus, chikungunya and influenza H5N1.

Too many delays in vaccine delivery

Due to the unpredictable nature of the zoonotic outbreaks, the rapid development of containment and control programmes is critical to the well-being of both human and animal populations. Current vaccine development platforms, however, may not be appropriate to come up with effective products that can trigger a protective response. Additionally, in most cases these platforms rely on cell lines from mammals, which may not be readily available and may not yield enough material to address outbreaks. Furthermore, long regulatory processes for product approval may delay their applications. All of this results in unacceptable delays in vaccine delivery to the populations in needs. 

Collaborative approach needed 

Zoonoses clearly demonstrate that the health of the people is closely interlinked with the health of the animals and the environment – these types of diseases require a ‘One Health’ approach to research, which includes measures in the human and veterinary field. Today, no individual organisation has either the expertise or the resources available to ensure full readiness for delivering efficient control tools against future outbreaks. Therefore, close collaboration among governmental regulatory agencies, academic groups and industrial partners is a must for achieving such an ambitious objective.

What does ZAPI bring to the table?

By bringing together more than 20 partners, including leading human and veterinary research institutions, non-governmental organisations, regulatory agencies, academic groups and manufacturers, ZAPI aims to shorten the time to respond to emerging infectious diseases by using a multidisciplinary, One Health approach. The project aims to produce both platforms for the rapid production of veterinary vaccines and antibodies to protect the human population. The project also aims to ensure fast-track registration and implementation of the control tools after the emergence of the disease. 

More specifically, the project is working towards:

  • creating platforms that allow rapid identification and production of antibodies capable of neutralising emerging viruses; 
  • creating platforms suitable for rapid increases in the production of vaccines;
  • enabling the development of quality control assays that do not make use of animals;
  • establishing protocols for fast track registration of developed products.

Focusing on three key viruses

It is less expensive to control new infectious diseases in animals compared to the high costs triggered when the disease spreads to people. Therefore, the focus of the project is on three pathogens which occur first in animals before moving to people. 

  • Rift Valley fever virus causes recurrent outbreaks among ruminants (e.g. cattle, sheep and goats) and humans across the African continent, several islands of the Western Indian Ocean, and the Arabian peninsula. It is transmitted by mosquitoes. Infection can cause severe illness and/or death in animals and humans, as well as economic losses due to death and abortion among infected livestock.
  • Schmallenberg virus is associated with abortions, stillbirths and malformations in ruminants in Asia, Africa and Oceania. It emerged in Europe for the first time in 2011 and is transmitted by mosquitoes. No evidence of human infection has been reported but related viruses have zoonotic potential.
  • Middle East respiratory syndrome coronavirus first emerged in the Arabian peninsula in 2012, causing severe lower respiratory tract disease in humans. Approximately 36% of the reported patients have died. Camels are likely to be a major animal source of infection in humans.

Significant impact while reducing animal testing

ZAPI’s innovative approaches aim to result in significant scientific and technological impact, leading to a faster response to newly emerging viruses. Furthermore, the ZAPI platform will reduce the number of animal experiments necessary for the development of vaccines, and will minimize the need for control tests in animals for the regulatory release of commercial vaccine batches.

Achievements so far

A year after the launch, the project is already yielding its first results. The results generated so far confirm the initial hypothesis that it should be possible to generate viral vaccines based on small subunits expressed in systems other than the classical mammalian or avian cells. Additionally, some of the project milestones have already been achieved ahead of schedule including the generation of key neutralizing antibodies against all 3 target viruses. In addition,  a consensus on industrial and regulatory processes needed to deliver key vaccines and/or antibodies in quantities needed to address outbreaks was obtained; methodology to determine constraints and criteria for the selection of systems for industrial scale-up; as well as innovative advances for the design in vitro QC assays, and innovative advances in the design of vaccine candidates were developed. 

Achievements & News

COVID-19 is a sign of the times – an opinion piece by IMI’s Pierre Meulien
March 2020

This month IMI announced a new funding Call in reaction to the spread of COVID-19. The process is being fast-tracked, just like the call for Ebola projects in 2014. However, as IMI Executive Director Pierre Meulien points out in a new opinion piece published on the IMI website, there’s nothing unexpected about the emergence of these epidemics.###

‘Every year, viruses jump from animals to the human population, including certain strains of influenza,’ he writes. ‘The closer we live to animals, the more of these ‘jumps’ we’re going to see.’

The scientific community needs to get ready to respond regardless of where the next virus comes from. In that respect, two ongoing IMI projects now look particularly prescient: the ZAPI project was set up to deliver a platform and technologies to facilitate a rapid response to future disease outbreaks. In 2019, the project demonstrated that certain antibodies can stop the MERS coronavirus from infecting new cells, and they’re now assessing whether the antibodies could also be effective against SARS-CoV-2, the virus that causes COVID-19. COMBACTE-NET, part of the antimicrobial resistance programme, has set up a network of clinical and laboratory sites across Europe that has been mobilised to support global efforts to standardise the information gathered from patients with suspected or confirmed COVID-19.

COVID-19 has put everyone on the alert because there’s so much we don’t know about it. Dr Meulien concludes: ‘In the coming months, the scientific community will no doubt be able to answer more questions about the epidemiology and modes of transmission of the virus, and the story will gradually recede from the headlines. Meanwhile, the projects that will result from the IMI coronavirus call will outlast the news cycle, putting everything in place for the next outbreaks, wherever or however they may emerge.’

Read more

IMI’s ZAPI project: ‘This is like a real-life experiment for us’
March 2020

Zoonotic diseases are those that are transmitted from animals to humans. COVID-19 is zoonotic in origin, and experts believe such outbreaks could become increasingly frequent in the future. The best we can do - and must do - is be prepared. ###In 2015, IMI launched ZAPI (Zoonotic Anticipation and Preparedness Initiative) to set up tools and platforms that would be ready to put into production for vaccines and monoclonal antibodies (cloned copies of the body’s natural defences) to efficiently counter emerging or remerging diseases. Much of the project’s work on the Middle East respiratory syndrome (MERS) coronavirus, can be directly applied to SARS-CoV-2, the virus that causes COVID-19, as the two are closely related.

‘This scenario with COVID-19 is exactly the scenario that we are working to prevent in the future – of course it’s never exactly the same virus but one of our models, the MERS coronavirus that occurred a few years ago, has taught us a lot about how to design and manufacture antibodies and to test them,’ says project coordinator Jean-Christophe Audonnet of Boehringer Ingelheim.

‘As we have seen, the diseases are coming very fast, and it’s very difficult to react very efficiently to the different factors. We want to show, however, what is technically possible,’ he continues. ‘It’s a real life experiment now for us. A factor that we need to explore better through dialogue is how we can reduce the timelines for the key decisions - political and regulatory ones. Maybe we have to reflect all together as a society how to overcome this.’

Read more

IMI’s vaccine projects in the spotlight
May 2019

In the run-up to World Immunisation Week 2019, the IMI Programme Office caught up with three projects working in this important area.###

  • Vaccines are one of the most effective public health measures out, yet public distrust in immunisation programmes is limiting high vaccine uptake, resulting in outbreaks of vaccine-preventable infectious diseases that had almost disappeared. ADVANCE has paved the way for an open system for actively monitoring vaccine coverage, benefits and risks in Europe. Read more
  • Zoonoses are infectious diseases that can be transmitted to humans from animals (and vice versa). IMI's ZAPI project is working to create new platforms and technologies that will facilitate a fast, coordinated, and practical response to new infectious diseases as soon as they emerge. Read more
  • Every year, pharmaceutical companies develop vaccines designed specifically to combat the strains of influenza (flu) that are most likely to be in circulation the following winter. However, accurately predicting how much protection a new vaccine would actually offer against emerging virus types is far from easy. The FLUCOP project is developing tools to address this challenge. Read more

World Immunisation Week is organised by the World Health Organization at the end of April every year.

Participants Show participants on map

EFPIA companies
  • Astrazeneca AB, Södertälje, Sweden
  • Boehringer Ingelheim Vetmedica GMBH, Ingelheim am Rhein, Germany
  • Merial SAS, Lyon, France
Universities, research organisations, public bodies, non-profit groups
  • Academisch Ziekenhuis Leiden, Leiden, Netherlands
  • Agencia Estatal Consejo Superior Deinvestigaciones Cientificas, Madrid, Spain
  • Association Internationale De Standardisation Biologique Pour L'Europe (IABS-EU), Lyon, France
  • Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands
  • Friedrich Loeffler Institut - Bundesforschungsinstitut Fuer Tiergesundheit, Greifswald-Insel Riems, Germany
  • Institut De Recerca I Tecnologia Agroalimentaries, Caldes De Montbui- Barcelona, Spain
  • Institut Pasteur, Paris, France
  • Stichting Wageningen Research, Wageningen, Netherlands
  • Stiftung Tieraerztliche Hochschule Hannover, Hannover, Germany
  • Universitatsklinikum Bonn, Bonn, Germany
  • Universite D'Aix Marseille, Marseille, France
  • Universiteit Utrecht, Utrecht, Netherlands
Small and medium-sized enterprises (SMEs)
  • Artemis Bio-Support B.V., Utrecht, Netherlands
  • Dyadic Nederland BV, Wageningen, Netherlands
  • Finovatis, Lyon, France
  • Harbour Antibodies BV, Rotterdam, Netherlands
  • Viroclinics Biosciences BV, Rotterdam, Netherlands
Project coordinator
Jean-Christophe Audonnet
Merial S.A.S
France
Managing entity
Ab Osterhaus
Erasmus Universitair Medisch Centrum Rotterdam