PERISCOPE

PERtussIS COrrelates of Protection Europe
Periscope logo

FACTS & FIGURES

Start Date
End Date
Call
IMI2 - Call 3
Grant agreement number
115910

Contributions
IMI Funding
21 000 000
EFPIA in kind
7 125 114
Other
1 801 572
Total Cost29 926 686

Summary

Vaccines have helped to cut cases of pertussis (whooping cough) worldwide. However, recent years have seen a rise in cases and the disease remains a leading cause of infant mortality around the world. The PERISCOPE project is working to better understand how the currently available vaccines work, and to aid the development and licensing of the next generation of improved pertussis vaccines. The multi-disciplinary team will focus on three major areas. Firstly, they will set up a comprehensive clinical research programme to study the immune response of people of all ages to pertussis infection and vaccination. Secondly, they will establish tools (clinical and pre-clinical models) to study pertussis infection. Finally, they will develop a battery of state-of-the-art tests, to help reveal the markers of an effective and long-lasting immune response to pertussis infection. PERISCOPE will also seek to study immunisation in pregnancy to gain a better understanding of the impact of maternal antibodies on the infant’s immune responses to pertussis.

Achievements & News

PERISCOPE launches first of nine clinical studies
June 2017

Recruitment is now open for the first clinical study under IMI’s whooping cough project PERISCOPE. The team at the UK’s University Hospital Southampton is running the study, during which healthy adults will be exposed to the bacteria Bordetella pertussis, which causes whooping cough. Through the study, scientists hope to learn more about the immune response generated against B. pertussis and what kind of immune response protects against whooping cough. Whooping cough, also known as pertussis, causes severe coughing and can be life threatening for young children and the elderly. Although a vaccine exists, is widely used and is very effective, the incidence of whooping cough has increased in recent years and scientists are keen to find out why. By delivering tools and knowledge on the disease, PERISCOPE contributes to efforts to develop new, better vaccines against whooping cough.

Participants Show participants on map

EFPIA companies
  • GlaxoSmithKline Biologicals S.A, Rixensart, Belgium
  • Sanofi Pasteur, Lyon, France
Universities, research organisations, public bodies, non-profit groups
  • (UK) Department of Health, Leeds, United Kingdom
  • Academisch Ziekenhuis Leiden - Leids Universitair Centrum, Leiden, Netherlands
  • AmatsiQBiologicals NV
  • Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • Commissariat à l’Energie Atomique et aux Energies Alternatives, Paris, France
  • Imperial College of Science, Technology and Medicine, London, United Kingdom
  • Institut Pasteur De Lille, Lille, France
  • Institute of Microbiology of the ASCR, v. v. i., Prague 4, Czech Republic
  • Rijksinstituut voor Volksgezondheid en Milieu (National Institute for Public Health and the Environment), Bilthoven, Netherlands
  • Stichting Katholieke Universiteit / Radboud university medical center, Nijmegen, Netherlands
  • The Medical Research Council, Swindon, United Kingdom
  • The Provost, Fellows, Foundation Scholars and the other members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin, Dublin, Ireland
  • Universidad de Salamanca, Salamanca, Spain
  • Universitaet Basel, Basel, Switzerland
  • University of Bath, Bath, United Kingdom
  • University of Oxford, Oxford, United Kingdom
  • University of Southampton, Southampton, United Kingdom
  • University of Turku, Turku, Finland
  • Université Libre de Bruxelles, Bruxelles, Belgium
Small and medium-sized enterprises (SMEs) and mid-sized companies (<€500 m turnover)
  • European Research and Project Office GmbH, Saarbrücken, Germany
Associated partners
  • Bill & Melinda Gates Foundation, Seattle, United States of America
Third parties
  • Institut National De La Sante Et De La Recherche Medicale, Paris, France
  • Universitats-Kinderspital Beider Basel, Basel, Switzerland

CONTACT

Project coordinator
de Groot Ronald
Stichting Katholieke Universiteit, more particularly the Radboud university medical center
+31 243667347
Ronald.deGroot[at]radboudumc.nl
EFPIA Coordinator
Patricia Londoño-Hayes
Sanofi Pasteur