To address these challenges, the Open PHACTS project will develop an open access innovation platform, called Open Pharmacological Space (OPS), via a semantic web approach. OPS will be comprised of data,vocabularies and infrastructure needed to accelerate drug-oriented research. The aim is to develop an enabling resource for drug discovery projects which is open to all users and freely available in the public domain.
This semantic integration hub will remove key bottlenecks in small molecule drug discovery, such as disparate information sources, and lack of standards and common identifiers. In order to ensure broad applicability in pharmaceutical research, the development of OPS will be guided by well-defined research questions from drug discovery.
Workflows for data capture, processing, interoperability, visualization, chemogenomics will all be developed creating a comprehensive Systems Chemical Biology Analysis Network. Security issues around proprietary data, shared via the nanopublication system and accessible for safe querying and reasoning, will be properly addressed with expert trusted parties.
The Open PHACTS consortium comprises 21 European academic and SME partners, with leading experts in the fields of data mining, annotation, small molecule data storage and manipulation, target bioinformatics, RDF information handling, massive in silico reasoning and chemical biology. The 10 EFPIA members of Open PHACTS will contribute drug discovery expertise, data sets, software engineering and programming capacity to the project.