IMI Members
Table of Contents
This page contains scientific publications from the IMI Executive Office and from IMI projects
Articles by the IMI Executive Office and governing bodies
Nature Reviews Drug Discovery, published online 30 March 2012
Denee, T.R. et al. (2012) Measuring the value of public–private partnerships in the pharmaceutical sciences
Nature Medicine, Vol. 18, p. 341
Goldman, M. (2012) Public-private partnerships need honest brokering
(Full article available until 4 July 2012)
Clinical Pharmacology and Therapeutics, Vol. 91 (3), pp. 418-125
Goldman, M. (2012) The Innovative Medicines Initiative: A European Response to the Innovation Challenge
(Full article available until 1 June 2012)
Nature Biotechnology, Vol. 29, pp. 689–690
Strohmeier, R. et al. (2011) IMI moves forward
Nature Reviews Drug Discovery, Vol. 10, pp. 321-322
Goldman, M. (2011) Reflections on the Innovative Medicines Initiative
Nature, Vol. 466, pp. 1040-1041
Goldman, M. and De Rijck, K. (2010) Opinion: Clarifying knowledge ownership in Europe’s medicines initiative
BTCure
Arthritis & Rheumatism, published online 5 March 2012
Snir, O. et al. (2012) Multifunctional T cell reactivity to native and glycosylated type-II collagen in rheumatoid arthritis
Archives of Disease in Childhood, published online 22 February
Hansson, M.G. et al. (2012) Ethics bureaucracy: a significant hurdle for collaborative follow-up of drug effectiveness in rare childhood diseases
Annals of the Rheumatic Diseases, Vol. 70, pp. 2184-2190
Vazgiourakis, V. M. et al. (2011) A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis
Annals of the Rheumatic Diseases, published online 13 October 2011
Willemze, A. et al. (2011) The ACPA recognition profile and subgrouping of ACPA-positive RA patients
Proceedings of the National Academy of Sciences, Vol. 108 (42), pp. 17372-17377
Shi, J. et al. (2011) Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
Trends in Immunology, Vol. 32 (6), pp. 278-286
Cope, A. et al. (2011) The Th1 life cycle: molecular control of IFN-γ to IL-10 switching
EHR4CR
iHealth Connections, ;1(2):108–13, published on-line.
Kalra, D. et al. (2011) Case Report from the EHR4CR Project—A European Survey on Electronic Health Records Systems for Clinical Research
EMTRAIN
European Journal of Pharmaceutical Sciences, 45 (5), pp. 515-520
Klech, H. et al. (2012) European initiative towards quality standards in education and training for discovery, development and use of medicines
eTOX
International Journal of Molecular Sciences, Vol. 13 (3), pp. 3820-3846
Briggs, K. et al. (2012) Inroads to predict in vivo toxicology - an introduction to the eTOX project
Nature Biotechnology, Vol. 29 (9), pp. 789-790
Mestres, J. et al. (2011) Shaping the future of safer innovative drugs in Europe
Environmental Health Perspectives, published online 17 August 2011
Audouze K. & Grandjean P. (2011) Application of computational systems biology to explore environmental toxicity hazards
Critical Reviews in Toxicology, Vol. 41 (9), pp. 783-802
Enoch, S. J. et al. (2011) A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity
PLoS ONE, Vol. 6 (6), e20284
Bauer-Mehren A. et al. (2011) Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases
Journal of Chemical Information and Modeling, Vol. 51, pp. 483-92
Obiol-Pardo, C. et al. (2011) A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity
Combinatorial Chemistry & High Throughput Screening, Vol. 14, No 5, pp. 375-387
Taboureau, O. and Jørgensen, F.S. (2011) In silico predictions of hERG channel blockers in drug discovery: From ligand-based and target-based approaches to systems chemical biology
Nucleic Acids Research, Vol. 9 (Suppl. 1): D367-D372
Taboureau, O. et al. (2011) ChemProt: a disease chemical biology database
Bioinformatics, Vol. 26, pp. 2924-2926
Bauer-Mehren, A. et al. (2010) DisGeNET - a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks
Expert Opinion on Drug Metabolism & Toxicology, Vol. 6, pp. 1253-1263
Garcia-Serna, R. and Mestres, J. (2010) Anticipating drug side effects by comparative pharmacology
Molecular Informatics, Vol. 29, pp. 543-551
Vidal, D. and Mestres, J. (2010) In silico receptorome screening of antipsychotic drugs
PLoS Computational Biology, Vol. 6(5): e1000788
Audouze, K. et al. (2010) Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks
Eu2P
European Journal of Pharmaceutical Sciences, 45 (5), pp. 515-520
Klech, H. et al. (2012) European initiative towards quality standards in education and training for discovery, development and use of medicines
Europain
Regional Anesthesia & Pain Medicine, May/June 2012, Volume 37, Issue 3, pages 340–343
Werner, M.U. et al. Pulsed Radiofrequency in the Treatment of Persistent Pain After Inguinal Herniotomy: A Systematic Review
European Journal of Pain, Volume 16, Issue 4, pages 485–495
Andrews, N. et al. (2012) Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain
Surgical Endoscopy, Volume 26, Number 4, pages 979-983
Bischoff, J.M. et al. (2012) Dysejaculation after laparoscopic inguinal herniorrhaphy: a nationwide questionnaire study
Anesthesia & Analgesia, published online 30 March 2012
Bischoff, J.M. et al. Ultrasound-Guided Ilioinguinal/Iliohypogastric Nerve Blocks for Persistent Inguinal Postherniorrhaphy Pain: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial
Clinical Journal of Pain, Volume 28, Issue 2, pages 136–142
Wildgaard, K. et al (2012) Neurophysiological characterisation of persistent post-thoracotomy pain
The Breast, Volume 21, Issue 1, pages 46–49
Andersen, K.G. et al. (2012) Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: a randomized trial
British Journal of Anaethesia, Volume 108, Issue 1, pages 126-133, published online October 2011
Wildgaard, K.et al. (2012) Quantitative sensory testing of persistent pain after video-assisted thoracic surgery lobectomy
European Journal of Pain Supplements, Volume 4, Issue S4, pages 203–207
Werner, M.U. et al. (2012) Characterization of persistent postoperative pain by quantitative sensory testing
PAIN, Journal for the International Association for the Study of Pain (IASP), Volume 153, Issue 1, pages 42-55
Serra, J. et al. (2012) Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states of humans and rats
Hernia, Volume 15, Number 5, pages 521-529
Linderoth, G. et al. (2011) Neurophysiological characterisation of persistent pain after laparoscopic inguinal hernia repair
PAIN, Journal for the International Association for the Study of Pain (IASP), Volume 152, Issue 10 , Pages 2312-2322
Sikandar, S. et al. (2011) Pregabalin modulation of spinal and brainstem visceral nociceptive processing
Techniques in Regional Anesthesia and Pain Management, Volume 15, Issue 3, pages 83–89
Wildgaard, K. et al. (2011) Chronic post-thoracotomy pain—What is new in pathogenic mechanisms and strategies for prevention?
The Journal of Pain, Volume 12, Issue 7, pages 725-746
Andersen, K. G. et al. (2011) Persistent pain after breast cancer treatment: A critical review of pathogenic mechanisms and strategies for prevention
Scandinavian Journal of Pain, Volume 2, Issue 3 , pages 139-145
Baastrup, C. et al. (2011) Coexisting mechanical hypersensitivity and anxiety in a rat model of spinal cord injury and the effect of pregabalin, morphine, and midazolam treatment
Science Translational Medicine, Volume 3, Issue 90, pages 90 ra60
Dawes J.M. et al. (2011) CXCL5 mediates UVB irradiation induced pain
NeuroImage, Volume 57, Issue 1, pages 206–213
Riedl, V. et al. (2011) Repeated pain induces adaptations of intrinsic brain activity to reflect past and predict future pain
PAIN, Journal for the International Association for the Study of Pain (IASP), Volume 152, Issue 2, pages 343–353
Serra, J. et al. (2011) Double and triple spikes in C-nociceptors in neuropathic pain states: An additional peripheral mechanism of hyperalgesia
Brain Research, Volume 1370, pages 129–135
Baastrup, C. et al. (2011) Pregabalin attenuates place escape/avoidance behavior in a rat model of spinal cord injury
Acta Anaesthesiologica Scandinavica, Volume 55, Issue 1, pages 60–68
Wildgaard, K. et al. (2011) Consequences of persistent pain after lung cancer surgery: a nationwide questionnaire study
Science Translational Medicine, Volume 3, No 90, pp. 90ra60
Dawes, J. M. et al. (2011) CXCL5 mediates UVB irradiation–induced pain
Journal of Pain, Volume 12, Issue 7, Pages 764-773
Binder, A. et al. (2011) Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model
Philosophical Transactions of the Royal Society Biological Sciences, Volume 366 (1572), 1913-1921
Vase, L. et al. (2011) Patients' direct experiences as central elements of placebo analgesia
PAIN, Journal for the International Association for the Study of Pain (IASP), Volume 151, Issue 3, Pages 670-679
Baastrup, C. et al. (2010) Spinal-, brainstem- and cerebrally mediated responses at- and below-level of a spinal cord contusion in rats: evaluation of pain-like behavior
Anesthesiology, Volume 112, Issue 4, pages 957-969
Aasvang, E. K. et al. (2010) Predictive Risk Factors for Persistent Postherniotomy Pain
IMIDIA
PLoS ONE, Vol. 7, Issue 5, ArticleID e36188
Martino, et al. (May 2012) Palmitate Activates Autophagy in INS-1E b-Cells and in Isolated Rat and Human Pancreatic Islets
Proceedings of the National Academy of Sciences, Vol. 108 (51), pp. 20719-20724
Virostko, J. et al. (2011) Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands
Journal of Clinical Investigation, Vol. 121 (12), pp. 4870-4879
Klee, P. et al. (2011) Connexins protect mouse pancreatic beta cells against apoptosis
Journal of Biological Chemistry, published online 7 November 2011
Semplici, F. et al. (2011) A human mutation within the per-ARNT-sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion
Diabetes, Vol. 60 (11), pp. 2853-2860
Lamprianou, L. et al. (2011) High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets
Diabetes, Vol. 60 (11), pp. 2872-2882
Thorel, F. et al. (2011) Normal glucagon signaling and beta-cell function after near-total alpha-cell ablation in adult mice
Journal of Clinical Investigation, Vol. 121 (9), pp. 3589-3597
Ravassard, P. et al. (2011) A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion
Commentary: Finally! A human pancreatic beta cell line
Journal of Visualized Experiments, Vol. 53, Article ID 2962
Bötticher, G. et al. (2011) Isolation of Human Islets from Partially Pancreatectomized Patients
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1813 (10), pp. 1827-1835
Mehmeti, I. et al. (2011) Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation
Journal of Molecular Medicine, Vol. 89 (8), pp. 785-798
Gurgul-Convey, E. et al. (2011) Cytokine toxicity in insulin-producing cells is mediated by nitrooxidative stress-induced hydroxyl radical formation in mitochondria
Diabetologica, (in press)
Koivisto, V. A. et al. The Innovative Medicines Initiative – a public private partnership to promote European diabetes research
MARCAR
PLoS ONE, Vol.7, Issue 4, Article ID e35327
Wrzodek, C. et al. (April 2012), Linking the Epigenome to the Genome: Correlation of Different Features to DNA Methylation of CpG Islands
Toxicological Sciences, published online 24 January
Schmid, A. et al. (2012) Quantitative Analysis of the Growth Kinetics of Chemically-Induced Mouse Liver Tumors by Magnetic Resonance Imaging
PLoS One, Vol. 6 (3), e18216
Lempiäinen, H. et al. (2011) Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice
NEWMEDS
Neuropsychopharmacology, published online 19 October 2011
Kargieman, L. et al. (2011) Clozapine reverses phencyclidine-induced desynchronization of prefrontal cortex through a 5-HT1A receptor-dependent mechanism
Biological Psychiatry, Vol. 69 (10), pp. 918-927
Santana, N. et al. (2011) Activation of thalamocortical networks by the N-methyl-D-aspartate receptor antagonist phencyclidine: reversal by clozapine
Frontiers in Psychiatry, Vol. 2, article 14
Kiss, T. et al. (2011) Role of thalamic projection in NMDA receptor-induced disruption of cortical slow oscillation and short-term plasticity
Psychopharmacology, Vol. 217 (2), pp. 255-269
Smith, J. et al. (2011) A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory
American Journal of Psychiatry, Vol. 168, pp. 408-417
Ingason, A. et al. (2011) Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness
Cerebral Cortex, published online 5 September 2011
Lladó-Pelfort, L. et al. (2011) 5-HT1A Receptor Agonists Enhance Pyramidal Cell Firing in Prefrontal Cortex Through a Preferential Action on GABA Interneurons
Neuropharmacology, published online 21 April 2011
Bussey, T. et al. (2011) New translational assays for preclinical modelling of cognition in schizophrenia: The touchscreen testing method for mice and rats
Psychopharmacology, Vol. 212 (2), pp. 227-242
Dix, S. et al. (2010) A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists
Synapse, Vol. 64 (7), pp. 573-577
Finnema, S. et al. (2010) Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain
PharmaCog
Human Brain Mapping (in press)
Babiloni, C. et al. (2012) Resting state cortical EEG rhythms are related to gray matter volume in subjects with mild cognitive impairment and Alzheimer’s disease: an ADNI project
Chronobiology International (in press)
Pifferi et al. (2012) The sleep-wake cycle in the non-human primate grey mouse lemur (Microcebus murinus): effects of dietary resveratrol supplementation
Journal of Alzheimer's disease, Vol. 26, Supplement 3, pp. 159-199
Drago, V. et al. (2011) Disease Tracking Markers for Alzheimer’s Disease at the Prodromal (MCI) Stage
Clinical Neurophysiology, published online 15 September 2011
Babiloni, C. et al. (2011) Cortical sources of resting state electroencephalographic rhythms in Parkinson’s disease related dementia and Alzheimer’s disease
Journal of Alzheimer’s Disease, Vol. 26 (2), pp. 331-346
Babiloni, C. et al. (2011) Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer’s disease: An Italian multicentre study
Ageing Research Reviews, published online 19 July 2011
Languille, S. et al. (2011) The grey mouse lemur: A non-human primate model for ageing studies
Journal of Alzheimer’s Disease, Vol. 22 (4), pp. 1047-64
Babiloni, C. et al. (2010) Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study
Human Brain Mapping, Vol. 32 (11), pp. 1916–1931
Babiloni, C. et al. (2010) Stability of clinical condition in mild cognitive impairment is related to cortical sources of alpha rhythms: An electroencephalographic study
NeuroMolecular Medicine, Vol. 13 (2), pp. 117-137
Balducci, C. (2010) APP transgenic mice: their use and limitations
Ricerca & Pratica, Vol. 26 (5), pp. 183-192
Forloni, G. (2010) Traslazionale o semplicemente razionale: la ricerca per la malattia di Alzheimer
Alzheimer’s and Dementia, Vol. 6 (3), pp. 280-285
Frisoni, G. B. (2010) Alzheimer’s Disease Neuroimaging Initiative in Europe
PharmaTrain
European Journal of Pharmaceutical Sciences, 45 (5), pp. 515-520
Klech, H. et al. (2012) European initiative towards quality standards in education and training for discovery, development and use of medicines
PROactive
Health and Quality of Life Outcomes, Vol. 9, Article 86
Gimeno-Santos, E. et al. (2011) Validity of instruments to measure physical activity may be questionable due to a lack of conceptual frameworks: a systematic review
PROTECT
Pharmacoepidemiology and Drug Safety, published online 23 September 2011
Groenwold, R. et al. (2011) Balance measures for propensity score methods: a clinical example on beta-agonist use and the risk of myocardial infarction
Pharmacoepidemiology and Drug Safety, published online 29 July 2011
Belitser, S. et al. (2011) Measuring balance and model selection in propensity score methods
European Journal of Epidemiology, published online 29 July 2011
Groenwold, R. et al. (2011) Selection of confounding variables should not be based on observed associations with exposure
QuIC-ConCePT
European Journal of Cancer, published online 5 January 2012
Sinkus, R. et al. (2012) Apparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug development
European Journal of Cancer, published online 5 January 2012
Waterton, C. et al. (2012) Qualification of imaging biomarkers for oncology drug development
European Journal of Cancer, published online 29 December 2011
Soloviev, D. et al. (2011) [18F]FLT: An imaging biomarker of tumour proliferation for assessment of tumour response to treatment
SafeSciMET
European Journal of Pharmaceutical Sciences, 45 (5), pp. 515-520
Klech, H. et al. (2012) European initiative towards quality standards in education and training for discovery, development and use of medicines
SAFE-T
Drug Discovery Today, Vol. 16 (Issues 13-14), pp. 600-608
Matheis, K. et al. (2011) A generic optional strategy to qualify translational safety biomarkers
International Clinical Trials (ICT), Winter 2010, pp. 64-66
Keenan, J. (2010) Managing Drug Safety
Toxicology Letters, Vol. 189, Suppl. 1, pp. S157
Dieterle, F. et al. (2009) The European IMI SAFE-T Consortium: Qualification of translational safety biomarkers
SUMMIT
Diabetologica, Vol. 54 (5)
Koivisto, V. A. et al. (2011) The Innovative Medicines Initiative – a public private partnership to promote European diabetes research
Diabetologia, Vol. 54, pp. 2295-302
Ahluwalia, T. S. et al. (2011) Common variants in CNDP1 and CDNP2, and risk of nephropathy in type 2 diabetes.
Ultrasound in Medicine & Biology, Vol. 37 (10), pp. 1561–1570
Tortoli, P. et al. (2011) Simultaneous Ultrasound Assessment of Brachial Artery Shear Stimulus and Flow-Mediated Dilation during Reactive Hyperemia
Cardiovascular Diabetology, Vol. 10, article 59
Heinonen, S. E. et al. (2011) Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice
Journal of American College of Cardiology: Cardiovascular Imaging, Vol. 4, pp. 1294-1301
Silvola, J. et al. (2011) Effects of Age, Diet, and Type 2 Diabetes on the Development and FDG Uptake of Atherosclerotic Plaques
PLoS One, Vol. 6 (8): e23616
Barbarini, N. et al. (2011) Prediction of peptide reactivity with human IVIg through a knowledge-based approach
Journal of Systemics, Cybernetics and Informatics (in press)
Agakov, F. V. et al. (2011) Inference of Causal Relationships between Biomarkers and Outcomes in High Dimensions
(A shorter version has appeared and received the best paper award at Bio-Medical Informatics Conference 2010)
Advances in Neural Information Processing Systems (NIPS), Vol. 23
Agakov, F. V. et al. in eds. J. Lafferty et al. (2010) Sparse Instrumental Variables (SPIV) for Genome-Wide Studies
U-BIOPRED
Thorax, published online 23 November
Bel, E.H. et al. (2010) Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)
Chest, Vol. 137 (6), pp. 1410-1416
Auffray, C. et al. (2010) An integrative systems biology approach to understanding pulmonary diseases
Innovative Medicines Initiative 2010